Crystal structure of the endogenous agonist-bound prostanoid receptor EP3.

Nat. Chem. Biol.2019 Jan;15(1):8-10. Epub 2018 Dec 03

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Prostanoids are a series of bioactive lipid metabolites that function in an autacoid manner via activation of cognate G-protein-coupled receptors (GPCRs). Here, we report the crystal structure of human prostaglandin (PG) E receptor subtype EP3 bound to endogenous ligand PGE₂ at 2.90âÃ resolution. The structure reveals important insights into the activation mechanism of prostanoid receptors and provides a molecular basis for the binding modes of endogenous ligands.

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Crystal structure of the endogenous agonist-bound prostanoid receptor EP3.

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