ERK5‑regulated RERG expression promotes cancer progression in prostatic carcinoma.

Big mitogen‑activated protein kinase 1 [also named extracellular signal‑regulated kinase (ERK) 5] is activated by mitogens and oncogenic signals and is strongly implicated in tumorigenesis. Our previous investigation indicated that ERK5 can induce prostatic carcinoma cell proliferation by promoting entry into the S phase of the cell cycle. In the present study, microarray and western blot analysis revealed that ERK5 can inhibit Ras‑like oestrogen‑regulated growth inhibitor protein expression and that the inhibition of expression promotes prostatic carcinoma cell proliferation and migration. In addition, pathological analysis indicated that the duanyu1795G expression level was associated with the malignancy of prostatic carcinoma. Furthermore, an apoptotic assay and western blot analysis demonstrated that the downregulation of duanyu1795G expression inhibits apoptosis by regulating the protein expression levels of B cell lymphoma‑2 and c‑Myc. Moreover, a luciferase activity assay indicated that the nuclear factor‑κB pathway is associated with apoptosis in prostatic carcinoma. Therefore, these data suggested that ERK5‑regulated duanyu1795G expression plays a role in the progression of prostatic carcinoma, indicating that duanyu1795G may be a potential biomarker for the prognosis of patients with prostatic carcinoma.

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