例如:"lncRNA", "apoptosis", "WRKY"

Lymphangiogenesis and Lymph Node Metastasis in Oral Squamous Cell Carcinoma.

Anticancer Res.2018 Nov;38(11):6157-6162
Satomi Arimoto 1 , Takumi Hasegawa 2 , Daisuke Takeda 1 , Izumi Saito 1 , Rika Amano 1 , Masaya Akashi 1 , Takahide Komori 1
Satomi Arimoto 1 , Takumi Hasegawa 2 , Daisuke Takeda 1 , Izumi Saito 1 , Rika Amano 1 , Masaya Akashi 1 , Takahide Komori 1
+ et al

[No authors listed]

Author information
  • 1 Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
  • 2 Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan hasetaku@med.kobe-u.ac.jp.

摘要


BACKGROUND/AIM:Tumor lymphangiogenesis plays a key role in lymph node (LN) metastasis in oral squamous cell carcinoma (OSCC). The purpose of this study was to investigate podoplanin and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) and their relationship to nodal metastasis and other clinicopathological variables. PATIENTS AND METHODS:Podoplanin and LYVE-1 expression of the primary tumor and normal tissue were investigated by means of a quantitative real-time PCR assay and immunohistochemistry in samples from 33 cases of OSCC. RESULTS:The mRNA high expression levels of both genes had a statistically significantly higher rate of LN metastasis (p<0.01) and histological grade (p<0.01 for podoplanin, p<0.05 for LYVE-1). High expression of each gene, as shown by immunohistochemistry, had a statistically significant higher rate of LN metastasis (p<0.01 for podoplanin, p<0.05 for LYVE-1). CONCLUSION:Podoplanin and LYVE-1 were strongly associated with LN metastasis.

KEYWORDS: Oral squamous cell carcinoma, immunohistochemistry, lymph node metastasis, lymphangiogenesis, quantitative real-time PCR