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Makorin 1 Regulates Developmental Timing in Drosophila.

Mol. Cells. 2018 Dec 31;41(12):1024-1032. Epub 2018 Nov 06
Hong Thuan Tran 1 , Eunjoo Cho 1 , Seongsu Jeong 1 , Eui Beom Jeong 1 , Hae Sang Lee 2 , Seon Yong Jeong 3 , Jin Soon Hwang 2 , Eun Young Kim 1
Hong Thuan Tran 1 , Eunjoo Cho 1 , Seongsu Jeong 1 , Eui Beom Jeong 1 , Hae Sang Lee 2 , Seon Yong Jeong 3 , Jin Soon Hwang 2 , Eun Young Kim 1
+ et al

[No authors listed]

Author information
  • 1 Department of Brain Science, Ajou University Medical Center, Kyunggi-do 16499, Korea.
  • 2 Department of Pediatrics, Ajou University Medical Center, Kyunggi-do 16499, Korea.
  • 3 Department of Medical Genetics, Ajou University Medical Center, Kyunggi-do 16499, Korea.

摘要


The central mechanisms coordinating growth and sexual maturation are well conserved across invertebrates and vertebrates. Although mutations in the gene encoding makorin RING finger protein 3 (mkrn3 ) are associated with central precocious puberty in humans, a causal relationship has not been elucidated. Here, we examined the role of mkrn1, a Drosophila ortholog of mammalian makorin genes, in the regulation of developmental timing. Loss of MKRN1 in mkrn1exS prolonged the 3rd instar stage and delayed the onset of pupariation, resulting in bigger size pupae. MKRN1 was expressed in the prothoracic gland, where the steroid hormone ecdysone is produced. Furthermore, mkrn1exS larvae exhibited reduced mRNA levels of phantom, which encodes ecdysone-synthesizing enzyme and E74, which is a downstream target of ecdysone. Collectively, these results indicate that MKRN1 fine-tunes developmental timing and sexual maturation by affecting ecdysone synthesis in Drosophila. Moreover, our study supports the notion that malfunction of makorin gene family member, mkrn3 dysregulates the timing of puberty in mammals.

KEYWORDS: Drosophila, growth, makorin1, makorin3, sexual maturation