例如："lncRNA", "apoptosis", "WRKY"

Association Study of ARMC9 Gene Variants with Vogt-Koyanagi-Harada Disease in Japanese Patients.

Ocul. Immunol. Inflamm.2019;27(5):699-705. doi:10.1080/09273948.2018.1523438. Epub 2018 Nov 05
Tomoko Ohno 1 , Akira Meguro 1 , Masaki Takeuchi 1 , Takahiro Yamane 1 , Takeshi Teshigawara 2 , Nobuyoshi Kitaichi 3 , Yukihiro Horie 4 , Kenichi Namba 3 , Shigeaki Ohno 3 , Kumiko Nakao 5 , Taiji Sakamoto 5 , Tsutomu Sakai 6 , Tadashi Nakano 6 , Hiroshi Keino 7 , Annabelle A Okada 7 , Atsunobu Takeda 8 , Takako Fukuhara 8 , Hisashi Mashimo 9 , Nobuyuki Ohguro 9 , Shinichirou Oono 10 , Hiroshi Enaida 10 , Satoshi Okinami 11 , Nobuhisa Mizuki 1
Tomoko Ohno 1 , Akira Meguro 1 , Masaki Takeuchi 1 , Takahiro Yamane 1 , Takeshi Teshigawara 2 , Nobuyoshi Kitaichi 3 , Yukihiro Horie 4 , Kenichi Namba 3 , Shigeaki Ohno 3 , Kumiko Nakao 5 , Taiji Sakamoto 5 , Tsutomu Sakai 6 , Tadashi Nakano 6 , Hiroshi Keino 7 , Annabelle A Okada 7 , Atsunobu Takeda 8 , Takako Fukuhara 8 , Hisashi Mashimo 9 , Nobuyuki Ohguro 9 , Shinichirou Oono 10 , Hiroshi Enaida 10 , Satoshi Okinami 11 , Nobuhisa Mizuki 1
+ et al

[No authors listed]

Author information
  • 1 a Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine , Yokohama , Kanagawa , Japan.
  • 2 c Tsurumi Chuoh Eye Clinic , Yokohama , Kanagawa , Japan.
  • 3 e Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University , Sapporo , Hokkaido , Japan.
  • 4 d Department of Ophthalmology, Health Sciences University of Hokkaido , Sapporo , Hokkaido , Japan.
  • 5 f Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences , Kagoshima , Kagoshima , Japan.
  • 6 g Department of Ophthalmology, Jikei University School of Medicine , Tokyo , Minato-ku , Japan.
  • 7 h Department of Ophthalmology, Kyorin University School of Medicine , Tokyo , Mitaka , Japan.
  • 8 i Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University , Fukuoka , Fukuoka , Japan.
  • 9 j Department of Ophthalmology, Japan Community Health Care Organization Osaka Hospital , Osaka , Osaka , Japan.
  • 10 k Department of Ophthalmology, Saga University Faculty of Medicine , Saga , Saga , Japan.
  • 11 l Department of Ophthalmology, Kurashiki Central Hospital , Okayama , Kurashiki , Japan.

摘要

Purpose: To investigate whether variants in the ARMC9 gene encoding KU-MEL-1 are associated with Vogt-Koyanagi-Harada (VKH) disease in a Japanese population. Methods: We recruited 380 Japanese patients with VKH disease and 744 Japanese healthy controls to genotype seven single-nucleotide polymorphisms (SNPs) in ARMC9. We also performed imputation analysis of the ARMC9 region and 195 imputed SNPs were included in the statistical analysis. Results: We observed an increased frequency of the A allele of rs28690417 in patients compared with controls (P = 0.0097, odds ratio (OR) = 1.46). The A allele had a dominant effect on VKH disease risk (P = 0.011, OR = 1.51). However, these significant differences disappeared after Bonferroni correction (corrected P > 0.05). The remaining 201 SNPs did not show any significant association with disease risk. Conclusions: Our study suggests that ARMC9 variants do not play a critical role in the development of VKH disease.

KEYWORDS: , Vogt-Koyanagi-Harada disease, association study, single nucleotide polymorphism, susceptibility gene

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