Prolactin controls branchial clcn2c but not atp1a1a.2 in zebrafish Danio rerio.

This study examined the branchial epithelium of stenohaline zebrafish Danio rerio, and in particular Na⁺ -Cl^- cotransporter-like 2 (Slc12a10.2)-expressing ionocytes (Na⁺ -Cl^- cotransporter [Ncc]-cells), which mediate the active uptake of ions from freshwater environments. The study assessed whether the pituitary hormone prolactin (Prl) stimulates the expression of messenger (m)RNAs encoding a Clc Cl^- channel family member (clcn2c) and a Na⁺ -K⁺ -ATPase α1 subunit (atp1a1a.2) expressed in Ncc-cells. Branchial clcn2c, but not atp1a1a.2 levels, were sensitive to Prl both in vitro and in vivo. These observations suggest that Prl contributes to maintaining systemic Cl^- balance via the regulation of clcn2c.

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