Suppressing serum response factor inhibits invasion in cervical cancer cell lines via regulating Egrâ1 and epithelial-mesenchymal transition.
[No authors listed]
摘要
Serum response factor (SRF) is a transcription factor that has important roles in tumor progression. However, its role in cervical cancer cell proliferation and invasion remains unclear. The present study revealed that SRF silencing constrained cervical cancer cell proliferation and invasion via controlling early growth responseâ1 (Egrâ1). The results demonstrated that SRF was significantly increased in cervical cancer tissues and cell lines, compared with normal. Suppressing SRF, by using a lossâofâfunction experiment, constrained cervical cancer cell proliferation, invasion, and epithelialâmesenchymal transition. Furthermore, SRF knockdown significantly downregulated Egrâ1 expression in cervical cancer cell lines, and overexpression of Egrâ1 reversed the effect of SRF on cell proliferation, invasion, and epithelialâmesenchymal transition. Therefore, SRF may control cell proliferation and invasion by regulating Egrâ1 in cervical cancer.
KEYWORDS: {{ getKeywords(articleDetailText.words) }}
基因功能
- {{$index+1}}.{{ gene }}
原始数据
| Sample name | Organism | Experiment title | Sample type | Library instrument | Attributes | |||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| {{attr}} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| {{ dataList.sampleTitle }} | {{ dataList.organism }} | {{ dataList.expermentTitle }} | {{ dataList.sampleType }} | {{ dataList.libraryInstrument }} | {{ showAttributeName(index,attr,dataList.attributes) }} | |||||||||||||||||||||||||||||||||||||||||||||||||
文献解读
| {{ list.authorName }} {{ list.authorName }} |
