Different expressions of miR-125b and SOX30 in malignant lymphomas and their significance.
[No authors listed]
摘要
PURPOSE:To explore the roles of micro RNAs (miRs)-125b and SOX30 in malignant lymphomas. METHODS:The correction of miR-125b targeting SOX30 was examined by the luciferase reporter assay. The expression levels of miR-125b and SOX30 were tested by in situ hybridization and immunohistochemistry. RESULTS:miR-125b was able to bind to the 3'UTR of SOX30 gene and was negatively associated with SOX30. As compared with the reactive hyperplasia lymphatic samples, the higher (miR-125b) and lower (SOX30) rate was expressed positively in the malignant lymphomas, which was related to the stage and grade of malignancy. CONCLUSIONS:miR-125b can regulate SOX30 by binding to its 3'UTR. miR-125b and SOX30 act as diagnostic and therapeutic markers for malignant lymphoma.
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基因功能
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原始数据
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文献解读
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