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Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans.

Hum Mol Genet. 2019 Feb 01;28(3):515-523
Linda M Polfus 1 , Laura M Raffield 2 , Marsha M Wheeler 3 , Russell P Tracy 4 , Leslie A Lange 5 , Guillaume Lettre 6 , Amanda Miller 7 , Adolfo Correa 8 , Russell P Bowler 9 , Joshua C Bis 10 , Shabnam Salimi 11 , Nancy Swords Jenny 12 , Nathan Pankratz 13 , Biqi Wang 14 , Michael H Preuss 15 , Lisheng Zhou 16 , Arden Moscati 16 , Girish N Nadkarni 16 , Ruth J F Loos 17 , Xue Zhong 18 , Bingshan Li 18 , Jill M Johnsen 19 , Deborah A Nickerson 3 , Alex P Reiner 20 , Paul L Auer 7 , NHLBI Trans-Omics for Precision Medicine Consortium
Linda M Polfus 1 , Laura M Raffield 2 , Marsha M Wheeler 3 , Russell P Tracy 4 , Leslie A Lange 5 , Guillaume Lettre 6 , Amanda Miller 7 , Adolfo Correa 8 , Russell P Bowler 9 , Joshua C Bis 10 , Shabnam Salimi 11 , Nancy Swords Jenny 12 , Nathan Pankratz 13 , Biqi Wang 14 , Michael H Preuss 15 , Lisheng Zhou 16 , Arden Moscati 16 , Girish N Nadkarni 16 , Ruth J F Loos 17 , Xue Zhong 18 , Bingshan Li 18 , Jill M Johnsen 19 , Deborah A Nickerson 3 , Alex P Reiner 20 , Paul L Auer 7 , NHLBI Trans-Omics for Precision Medicine Consortium
+ et al

[No authors listed]

Author information
  • 1 Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • 2 Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
  • 3 Department of Genome Sciences, University of Washington Center for Mendelian Genomics, Seattle, WA, USA.
  • 4 Department of Biochemistry, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
  • 5 Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
  • 6 Montreal Heart Institute, Montréal, QC, Canada.
  • 7 Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
  • 8 Department of Pediatrics and Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
  • 9 Department of Medicine, National Jewish Health, Denver, CO, USA.
  • 10 Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.
  • 11 School of Medicine, University of Maryland, Baltimore, MD, USA.
  • 12 Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
  • 13 Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
  • 14 Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  • 15 Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • 16 Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • 17 Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • 18 Vanderbilt Genetics Institute, Nashville, TN, USA.
  • 19 Department of Medicine, University of Washington, Seattle, WA, USA.
  • 20 Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

摘要

E-selectin mediates the rolling of circulating leukocytes during inflammatory processes. Previous genome-wide association studies in European and Asian individuals have identified the ABO locus associated with E-selectin levels. Using Trans-Omics for Precision Medicine whole genome sequencing data in 2249 African Americans (AAs) from the Jackson Heart Study, we examined genome-wide associations with soluble E-selectin levels. In addition to replicating known signals at ABO, we identified a novel association of a common loss-of-function, missense variant in Fucosyltransferase 6 (FUT6; rs17855739,p.Glu274Lys, P = 9.02 × 10-24) with higher soluble E-selectin levels. This variant is considerably more common in populations of African ancestry compared to non-African ancestry populations. We replicated the association of FUT6 p.Glu274Lys with higher soluble E-selectin in an independent population of 748 AAs from the Women's Health Initiative and identified an additional pleiotropic association with vitamin B12 levels. Despite the broad role of both selectins and fucosyltransferases in various inflammatory, immune and cancer-related processes, we were unable to identify any additional disease associations of the FUT6 p.Glu274Lys variant in an electronic medical record-based phenome-wide association scan of over 9000 AAs.

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