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Emergence of immunoregulatory Ym1+Ly6Chi monocytes during recovery phase of tissue injury.

Sci Immunol. 2018 Oct 05;3(28)
Naoki Ikeda 1 , Kenichi Asano 1 , Kenta Kikuchi 1 , Yoshimi Uchida 1 , Hiroki Ikegami 1 , Ryo Takagi 1 , Satoshi Yotsumoto 1 , Takumi Shibuya 1 , Chieko Makino-Okamura 2 , Hidehiro Fukuyama 2 , Takashi Watanabe 3 , Masaki Ohmuraya 4 , Kimi Araki 5 , Gen Nishitai 1 , Masato Tanaka 6
Naoki Ikeda 1 , Kenichi Asano 1 , Kenta Kikuchi 1 , Yoshimi Uchida 1 , Hiroki Ikegami 1 , Ryo Takagi 1 , Satoshi Yotsumoto 1 , Takumi Shibuya 1 , Chieko Makino-Okamura 2 , Hidehiro Fukuyama 2 , Takashi Watanabe 3 , Masaki Ohmuraya 4 , Kimi Araki 5 , Gen Nishitai 1 , Masato Tanaka 6
+ et al

[No authors listed]

Author information
  • 1 Laboratory of Immune Regulation, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.
  • 2 Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
  • 3 Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.
  • 4 Department of Genetics, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
  • 5 Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Kumamoto, 860-0811, Japan.
  • 6 Laboratory of Immune Regulation, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan. mtanaka@toyaku.ac.jp.

摘要

Ly6Chi monocytes migrate to injured sites and induce inflammation in the acute phase of tissue injury. However, once the causes of tissue injury are eliminated, monocyte-derived macrophages contribute to the resolution of inflammation and tissue repair. It remains unclear whether the emergence of these immunoregulatory macrophages is attributed to the phenotypic conversion of inflammatory monocytes in situ or to the recruitment of bone marrow-derived regulatory cells de novo. Here, we identified a subpopulation of Ly6Chi monocytes that contribute to the resolution of inflammation and tissue repair. Ym1+Ly6Chi monocytes greatly expanded in bone marrow during the recovery phase of systemic inflammation or tissue injury. Ym1+Ly6Chi monocytes infiltrating into an injured site exhibited immunoregulatory and tissue-reparative phenotypes. Deletion of Ym1+Ly6Chi monocytes resulted in delayed recovery from colitis. These results demonstrate that a distinct monocyte subpopulation destined to act in immunoregulation is generated in bone marrow and participates in resolution of inflammation and tissue repair.

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