Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs).

Chem. Commun. (Camb.). 2018 Oct 11;54(82):11606-11609. doi:10.1039/c8cc06838k

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摘要

Perturbations of domain-domain interactions impact the function of type I fatty acid synthases. We identify interface point mutations that modulate fatty acid chain lengths, and explain their effect in changes of domain-domain binding energetics. Engineering of similar interfaces in related megasynthases may be exploited for custom synthesis of natural products.

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Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs).

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