The expression of somatostatin receptor 2 decreases during cyst growth in mice with polycystic kidney disease.
[No authors listed]
摘要
IMPACT analogs have been shown to halt cyst growth and progression of autosomal dominant polycystic kidney disease by several clinical trials. However, two studies suggest that the effect of the analog octreotide on kidney growth during the first year of treatment is reduced in the subsequent follow-ups and the kidney enlargement resumes. This biphasic change in kidney growth during octreotide treatment may be partially explained by alterations in expression. Here, we found that duanyu1942R2 is mainly expressed in distal tubules and collecting ducts in murine kidneys, and the expression of duanyu1942R2 decreases during cyst growth in two PKD mouse models. Our data may thus provide possible explanations for the lack of efficacy in long-term treatment with duanyu1942 analogs.
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基因功能
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原始数据
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文献解读
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