例如:"lncRNA", "apoptosis", "WRKY"

VEGF-B is a potent antioxidant.

Proc. Natl. Acad. Sci. U.S.A.2018 Oct 09;115(41):10351-10356. Epub 2018 Sep 24
Pachiappan Arjunan 1 , Xianchai Lin 1 , Zhongshu Tang 1 , Yuxiang Du 1 , Anil Kumar 1 , Lixian Liu 1 , Xiangke Yin 1 , Lijuan Huang 1 , Wei Chen 1 , Qishan Chen 1 , Zhimin Ye 1 , Shasha Wang 1 , Haiqing Kuang 1 , Linbin Zhou 1 , Kai Xu 2 , Xue Chen 3 , Haitao Zeng 4 , Weisi Lu 1 , Yihai Cao 5 , Yizhi Liu 1 , Chen Zhao 6 , Xuri Li 7
Pachiappan Arjunan 1 , Xianchai Lin 1 , Zhongshu Tang 1 , Yuxiang Du 1 , Anil Kumar 1 , Lixian Liu 1 , Xiangke Yin 1 , Lijuan Huang 1 , Wei Chen 1 , Qishan Chen 1 , Zhimin Ye 1 , Shasha Wang 1 , Haiqing Kuang 1 , Linbin Zhou 1 , Kai Xu 2 , Xue Chen 3 , Haitao Zeng 4 , Weisi Lu 1 , Yihai Cao 5 , Yizhi Liu 1 , Chen Zhao 6 , Xuri Li 7
+ et al

[No authors listed]

Author information
  • 1 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong, China.
  • 2 Department of Ophthalmology and Vision Science, Eye, Ear, Nose, and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai 200031, China.
  • 3 Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University and State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China.
  • 4 Center for Reproductive Medicine, The Sixth Zhongshan Ophthalmic Center, Sun Yat-sen University Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China.
  • 5 Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 77 14 Stockholm, Sweden.
  • 6 Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai 200031, China.
  • 7 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong, China; lixr6@mail.sysu.edu.cn dr_zhaochen@163.com.

摘要


VEGF-B was discovered a long time ago. However, unlike VEGF-A, whose function has been extensively studied, the function of VEGF-B and the mechanisms involved still remain poorly understood. Notwithstanding, drugs that inhibit VEGF-B and other VEGF family members have been used to treat patients with neovascular diseases. It is therefore critical to have a better understanding of VEGF-B function and the underlying mechanisms. Here, using comprehensive methods and models, we have identified VEGF-B as a potent antioxidant. Loss of Vegf-b by gene deletion leads to retinal degeneration in mice, and treatment with VEGF-B rescues retinal cells from death in a retinitis pigmentosa model. Mechanistically, we demonstrate that VEGF-B up-regulates numerous key antioxidative genes, particularly, Gpx1 Loss of Gpx1 activity largely diminished the antioxidative effect of VEGF-B, demonstrating that Gpx1 is at least one of the critical downstream effectors of VEGF-B. In addition, we found that the antioxidant function of VEGF-B is mediated mainly by VEGFR1. Given that oxidative stress is a crucial factor in numerous human diseases, VEGF-B may have therapeutic value for the treatment of such diseases.

KEYWORDS: Gpx1, VEGF-B, antioxidant, oxidative stress, retinal degeneration