Characterization of rabbit genes for synovial cell collagenase.
Arthritis Rheum.1986 Nov;29(11):1301-15. doi:10.1002/art.1780291102
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摘要
To provide tools for understanding collagenase gene expression in rheumatoid arthritis, we have isolated and characterized genomic clones for rabbit synovial cell collagenase. These clones represent 2 types of collagenase gene, at least 1 of which is transcribed in synovial fibroblasts. By examining the rabbit genome in situ, we provide evidence that there are only 2 different synovial cell collagenase genes found in a haploid genome. Amplification of these genes is not a mechanism for collagenase messenger RNA induction by phorbol esters.
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基因功能
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原始数据
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文献解读
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