例如:"lncRNA", "apoptosis", "WRKY"

The Significance of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Human Gliomas.

Int J Mol Sci. 2018 Sep 12;19(9)
Davide Schiffer 1 , Marta Mellai 2 , Renzo Boldorini 3 , Ilaria Bisogno 4 , Silvia Grifoni 5 , Cristiano Corona 6 , Luca Bertero 7 , Paola Cassoni 8 , Cristina Casalone 9 , Laura Annovazzi 10
Davide Schiffer 1 , Marta Mellai 2 , Renzo Boldorini 3 , Ilaria Bisogno 4 , Silvia Grifoni 5 , Cristiano Corona 6 , Luca Bertero 7 , Paola Cassoni 8 , Cristina Casalone 9 , Laura Annovazzi 10
+ et al

[No authors listed]

Author information
  • 1 Professor Emeritus of Neurology, University of Turin, Corso Bramante 88/90, 10126 Turin, Italy. davide.schiffer@unito.it.
  • 2 Department of Health Sciences, School of Medicine, University of Eastern Piedmont, 28100 Novara, Italy. martamel73@gmail.com.
  • 3 Department of Health Sciences, School of Medicine, University of Eastern Piedmont, 28100 Novara, Italy. renzo.boldorini@med.uniupo.it.
  • 4 Former Research Centre/Policlinico di Monza Foundation, Via P. Micca 29, 13100 Vercelli, Italy. ilaria.bisogno01@universitadipavia.it.
  • 5 Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, 10126 Turin, Italy. silvia.grifoni@izsto.it.
  • 6 Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, 10126 Turin, Italy. cristiano.corona@izsto.it.
  • 7 Department of Medical Sciences, University of Turin/Città della Salute e della Scienza, Via Santena 7, 10126 Turin, Italy. luca.bertero@unito.it.
  • 8 Department of Medical Sciences, University of Turin/Città della Salute e della Scienza, Via Santena 7, 10126 Turin, Italy. paola.cassoni@unito.it.
  • 9 Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'Aosta, 10126 Turin, Italy. cristina.casalone@izsto.it.
  • 10 Former Research Centre/Policlinico di Monza Foundation, Via P. Micca 29, 13100 Vercelli, Italy. lannov16@gmail.com.

摘要


Neuron glial antigen 2 (NG2) is a chondroitin sulphate proteoglycan 4 (CSPG4) that occurs in developing and adult central nervous systems (CNSs) as a marker of oligodendrocyte precursor cells (OPCs) together with platelet-derived growth factor receptor α (PDGFRα). It behaves variably in different pathological conditions, and is possibly involved in the origin and progression of human gliomas. In the latter, NG2/CSPG4 induces cell proliferation and migration, is highly expressed in pericytes, and plays a role in neoangiogenesis. NG2/CSPG4 expression has been demonstrated in oligodendrogliomas, astrocytomas, and glioblastomas (GB), and it correlates with malignancy. In rat tumors transplacentally induced by N-ethyl-N-nitrosourea (ENU), NG2/CSPG4 expression correlates with PDGFRα, Olig2, Sox10, and Nkx2.2, and with new vessel formation. In this review, we attempt to summarize the normal and pathogenic functions of NG2/CSPG4, as well as its potential as a therapeutic target.

KEYWORDS: CNS, NG2/CSPG4, development, gliomagenesis, vessels