The Expression of Actin-Related Protein 2/3 Complex Subunit 5 (ARPC5) Expression in Multiple Myeloma and its Prognostic Significance.

BACKGROUND The aim of this study was to analyze the prognostic value of in patients with multiple myeloma (MM). MATERIAL AND METHODS MM gene expression studies GSE6477, GSE31162, GSE24080, and GSE19784 were obtained and analyzed. The expression of duanyu37C5 was assessed in normal plasma cells, baseline MM cells, and relapsed MM cells. Univariate and multivariable analyses were used to determine the relationship between duanyu37C5 expression and clinical characteristics and survivals of MM patients. was used to detect the expression duanyu37C5 in bone marrow mononuclear cells of MM patients and normal controls. GSEA was conducted to identify associated mechanisms. RESULTS duanyu37C5 expression was significantly increased in baseline MM cells compared to normal plasma cells (P=0.0414). Meanwhile, duanyu37C5 was significantly increased in relapsed MM cells compared to baseline MM cells (P<0.0001). duanyu37C5 expression was significantly associated with β2-microglobin (P=0.047), serum lactate dehydrogenase (P=0.007), and rates of aspirate plasma cells (P=0.007). Meanwhile, patients in the duanyu37C5 high expression group were associated with poor overall survival (P=0.0027) and event-free survival (P=0.0102) compared to those in the duanyu37C5 low expression group. Multivariable analysis indicated that duanyu37C5 was an independent prognostic factor for MM patients. duanyu1587 demonstrated that duanyu37C5 was significantly increased in MM patients. GSEA results indicated that duanyu37C5 might affect cellular growth of myeloma cells through mammalian target of rapamycin (mTOR)C1 signaling pathway. CONCLUSIONS duanyu37C5 could be treated as an independent biomarker for patients with MM.

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