Genetic effect and combined genotype effect of ESR, FSHβ, CTNNAL1 and miR-27a loci on litter size in a Large White population.

To select new Large White line with high number of piglets born, genotypes of estrogen receptor (ESR), the follicle stimulating hormone β subunit (FSHβ), catenin alpha like 1 (CTNNAL1) and miR-27a were tested in 472 Large White sows. The associations of different genotypes with litter size traits were also studied. The results showed ESR^BB and FSHβ^BB sows produced 0.41-1.49 more pigs per litter (p < .05) for total number born (TNB) and number born alive (NBA) than did other corresponding genotypes. TNB of CTNNAL1^CG sows is 0.50 more pigs per litter (p < .05) than that of CTNNAL1^GG sows with the dominance effect of 0.25 pigs per litter (p < .05). miR-27a^BB sows had a less estimated breeding value (EBV) to TNB and had a more number of mummified pigs (NM) than did miR-27a^AA or miR-27a^AB sows (p < .05). Therefore, ESR^B, FSHβ^B, CTNNAL1^G, miR-27a^A allele was favorable for litter size traits. Furthermore, combined genetic effect analysis showed ESR^AAFSHβ^BB, ESR^AACTNNAL1^CG, ESR^AAmiR-27a^AA, FSHβ^BBCTNNAL1^CC, FSHβ^BBmiR-27a^AA and CTNNAL1^CG miR-27a^AB was the favorable combined genotype for litter size traits. These results identified favorable alleles and genotypes for litter size traits and suggested a potential selection scheme for litter size in Large White pigs.

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