例如："lncRNA", "apoptosis", "WRKY"

Plasma gelsolin promotes re-epithelialization.

Sci Rep. 2018 Sep 03;8(1):13140
J Wittmann 1 , J Dieckow 2 , H Schröder 1 , U Hampel 3 , F Garreis 1 , C Jacobi 4 , A Milczarek 1 , K L Hsieh 5 , B Pulli 5 , J W Chen 5 , S Hoogeboom 6 , L Bräuer 1 , F P Paulsen 1 , S Schob 7 , M Schicht 8
J Wittmann 1 , J Dieckow 2 , H Schröder 1 , U Hampel 3 , F Garreis 1 , C Jacobi 4 , A Milczarek 1 , K L Hsieh 5 , B Pulli 5 , J W Chen 5 , S Hoogeboom 6 , L Bräuer 1 , F P Paulsen 1 , S Schob 7 , M Schicht 8
+ et al

[No authors listed]

Author information
  • 1 Department of Functional and Clinical Anatomy, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
  • 2 Schepens Eye Research Institute and Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
  • 3 Department of Ophthalmology, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
  • 4 Clinic of Ophthalmology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
  • 5 Center for Systems Biology and Institute for Innovation in Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • 6 Frauenhofer Institute for Supply Chain Services SCS, Nürnberg, Germany.
  • 7 Department of Neuroradiology, University of Leipzig, Leipzig, Germany.
  • 8 Department of Functional and Clinical Anatomy, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany. martin.schicht@fau.de.

摘要

Woundhealing disorders characterized by impaired or delayed re-epithelialization are a serious medical problem that is painful and difficult to treat. Gelsolin (GSN), a known actin modulator, supports epithelial cell regeneration and apoptosis. The aim of this study was to estimate the potential of recombinant gelsolin (rhu-pGSN) for ocular surface regeneration to establish a novel therapy for delayed or complicated wound healing. We analyzed the influence of gelsolin on cell proliferation and wound healing in vitro, in vivo/ex vivo and by gene knockdown. Gelsolin is expressed in all tested tissues of the ocular system as shown by molecular analysis. The concentration of GSN is significantly increased in tear fluid samples of patients with dry eye disease. rhu-pGSN induces cell proliferation and faster wound healing in vitro as well as in vivo/ex vivo. TGF-β dependent transcription of SMA is significantly decreased after GSN gene knockdown. Gelsolin is an inherent protein of the ocular system and is secreted into the tear fluid. Our results show a positive effect on corneal cell proliferation and wound healing. Furthermore, GSN regulates the synthesis of SMA in myofibroblasts, which establishes GSN as a key protein of TGF-β dependent cell differentiation.

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