例如:"lncRNA", "apoptosis", "WRKY"

Endoplasmic reticulum stress impairs cardiomyocyte contractility through JNK-dependent upregulation of BNIP3.

Int. J. Cardiol.2018 Dec 01;272:194-201. Epub 2018 Aug 24
Luiz H M Bozi 1 , Ana P C Takano 2 , Juliane C Campos 2 , Natale Rolim 3 , Paulo M M Dourado 4 , Vanessa A Voltarelli 5 , Ulrik Wisløff 6 , Julio C B Ferreira 2 , Maria L M Barreto-Chaves 2 , Patricia C Brum 7
Luiz H M Bozi 1 , Ana P C Takano 2 , Juliane C Campos 2 , Natale Rolim 3 , Paulo M M Dourado 4 , Vanessa A Voltarelli 5 , Ulrik Wisløff 6 , Julio C B Ferreira 2 , Maria L M Barreto-Chaves 2 , Patricia C Brum 7
+ et al

[No authors listed]

Author information
  • 1 School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil; Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil; K.G. Jebsen Center of Exercise in Medicine, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology - NTNU, Trondheim, Norway.
  • 2 Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
  • 3 K.G. Jebsen Center of Exercise in Medicine, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology - NTNU, Trondheim, Norway.
  • 4 Heart Institute, University of Sao Paulo, 05403-900 Sao Paulo, Brazil.
  • 5 School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil.
  • 6 K.G. Jebsen Center of Exercise in Medicine, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology - NTNU, Trondheim, Norway; School of Human Movement & Nutrition Sciences, University of Queensland, Australia.
  • 7 School of Physical Education and Sport, University of Sao Paulo, Sao Paulo, Brazil. Electronic address: pcbrum@usp.br.

摘要


BACKGROUND:Disruption of endoplasmic reticulum (ER) homeostasis is a common feature of cardiac diseases. However, the signaling events involved in ER stress-induced cardiac dysfunction are still elusive. Here, we uncovered a mechanism by which disruption of ER homeostasis impairs cardiac contractility. METHODS/RESULTS:We found that ER stress is associated with activation of JNK and upregulation of BNIP3 in a post-myocardial infarction (MI) model of cardiac dysfunction. Of interest, 4-week treatment of MI rats with the chemical ER chaperone 4-phenylbutyrate (4PBA) prevented both activation of JNK and upregulation of BNIP3, and improved cardiac contractility. We showed that disruption of ER homeostasis by treating adult rat cardiomyocytes in culture with tunicamycin leads to contractile dysfunction through JNK signaling pathway. Upon ER stress JNK upregulates BNIP3 in a FOXO3a-dependent manner. Further supporting a BNIP3 mechanism for ER stress-induced deterioration of cardiac function, siRNA-mediated BNIP3 knockdown mitigated ER stress-induced cardiomyocyte dysfunction by reestablishing sarcoplasmic reticulum Ca2+ content. CONCLUSIONS:Collectively, our data identify JNK-dependent upregulation of BNIP3 as a critical process involved in ER stress-induced cardiomyocyte contractile dysfunction and highlight 4PBA as a potential intervention to counteract ER stress-mediated BNIP3 upregulation in failing hearts.

KEYWORDS: BNIP3, Cardiac dysfunction, Endoplasmic reticulum, FOXO3a, JNK, Myocardial infarction