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Taurine Transporter dEAAT2 is Required for Auditory Transduction in Drosophila.

Neurosci Bull. 2018 Dec;34(6):939-950. Epub 2018 Jul 24
Ying Sun 1 , Yanyan Jia 1 , Yifeng Guo 1 , Fangyi Chen 2 , Zhiqiang Yan 3
Ying Sun 1 , Yanyan Jia 1 , Yifeng Guo 1 , Fangyi Chen 2 , Zhiqiang Yan 3

[No authors listed]

Author information
  • 1 State Key Laboratory of Medical Neurobiology, Human Phenome Institute, Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai, 200438, China.
  • 2 Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, 518055, China. chenfy@sustc.edu.cn.
  • 3 Department of Human Anatomy, School of Basic Medicine Sciences, Southwest Medical University, Luzhou, 646000, China. zqyan@fudan.edu.cn.

摘要

Drosophila dEAAT2, a member of the excitatory amino-acid transporter (EAAT) family, has been described as mediating the high-affinity transport of taurine, which is a free amino-acid abundant in both insects and mammals. However, the role of taurine and its transporter in hearing is not clear. Here, we report that dEAAT2 is required for the larval startle response to sound stimuli. dEAAT2 was found to be enriched in the distal region of chordotonal neurons where sound transduction occurs. The Ca2+ imaging and electrophysiological results showed that disrupted dEAAT2 expression significantly reduced the response of chordotonal neurons to sound. More importantly, expressing dEAAT2 in the chordotonal neurons rescued these mutant phenotypes. Taken together, these findings indicate a critical role for Drosophila dEAAT2 in sound transduction by chordotonal neurons.

KEYWORDS: Chordotonal neurons, Drosophila dEAAT2, Sound transduction, Taurine

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