例如:"lncRNA", "apoptosis", "WRKY"

Mechanisms of Non-canonical Signaling in Health and Disease: Diversity to Take Therapy up a Notch?

Adv. Exp. Med. Biol.2018;1066:187-204. doi:10.1007/978-3-319-89512-3_9
Victor Alfred 1 , Thomas Vaccari 2
Victor Alfred 1 , Thomas Vaccari 2

[No authors listed]

Author information
  • 1 IFOM, Istituto FIRC di Oncologia Molecolare at IFOM-IEO Campus, Milan, Italy.
  • 2 Dipartimento di Bioscienze, Università degli Studi di Milano, Milan, Italy. thomas.vaccari@unimi.it.

摘要


Non-canonical Notch signaling encompasses a wide range of cellular processes, diverging considerably from the established paradigm. It can dispense of ligand, proteolytic or nuclear activity. Non-canonical Notch signaling events have been studied mostly in the fruit fly Drosophila melanogaster, the organism in which Notch was identified first and a powerful model for understanding signaling outcomes. However, non-canonical events are ill-defined and their involvement in human physiology is not clear, hampering our understanding of diseases arising from Notch signaling alterations. At a time in which therapies based on specific targeting of Notch signaling are still an unfulfilled promise, detailed understanding of non-canonical Notch events might be key to devising more specific and less toxic pharmacologic options. Based on the blueprint of non-canonical signaling in Drosophila, here, we review and rationalize current evidence about non-canonical Notch signaling. Our effort might inform Notch biologists developing new research avenues and clinicians seeking future treatment of Notch-dependent diseases.

KEYWORDS: Drosophila melanogaster, Ligand-independent signaling, NF-κB signaling, Non-canonical activation, Notch signaling, Wnt/β-catenin signaling, mTOR/Akt signaling