例如："lncRNA", "apoptosis", "WRKY"

Correlation between high expression levels of jumonji domain-containing 4 and short survival in cases of colon adenocarcinoma.

Biochem. Biophys. Res. Commun.2018 Sep 10;503(3):1442-1449. Epub 2018 Jul 17
Yi-Jung Ho 1 , Cheng-Ping Shih 2 , Kun-Tu Yeh 3 , Bingyang Shi 4 , Zhiyuan Gong 5 , Yueh-Min Lin 6 , Jeng-Wei Lu 7
Yi-Jung Ho 1 , Cheng-Ping Shih 2 , Kun-Tu Yeh 3 , Bingyang Shi 4 , Zhiyuan Gong 5 , Yueh-Min Lin 6 , Jeng-Wei Lu 7
+ et al

[No authors listed]

Author information
  • 1 School of Pharmacy, National Defense Medical Center, Taipei, Taiwan.
  • 2 Department of Otorhinolaryngology-Head and Neck Surgery, Tri-Service General Hospital, Taipei, Taiwan.
  • 3 Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
  • 4 International Joint Center for Biomedical Innovation, School of Life Sciences, Henan University, Kaifeng, Henan, PR China.
  • 5 Department of Biological Sciences, National University of Singapore, Singapore.
  • 6 Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan; Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan. Electronic address: 93668@cch.org.tw.
  • 7 Department of Biological Sciences, National University of Singapore, Singapore. Electronic address: jengweilu@gmail.com.

摘要

In this study, we investigated the expression of jumonji domain-containing 4 (JMJD4) in colon adenocarcinoma (CA) look for evidences for future studies on clinical diagnostic and prognostic value. The immunohistochemical (IHC) reactivity of JMJD4 was assessed in human tissue microarrays using monoclonal antibodies. An initial investigation revealed that the expression of JMJD4 protein was significantly higher in tumor tissue of the colon and liver than in normal tissue. Upon further investigation, we observed significant positivity of JMJD4 between 59 paired samples from CA tissue and adjacent normal tissue. JMJD4 protein expression in CA differed significantly according to the histological grade and M-class (distant metastasis). We also determined that the mRNA or protein expression of JMJD4 was significantly associated with poor survival in patients with CA. Finally, univariate and multivariate analysis revealed that JMJD4 expression could be a prognostic indicator for patients with CA and may provide a new target for the development of novel therapies for the treatment of CA.

KEYWORDS: Colon adenocarcinoma, Colorectal cancer, Immunohistochemistry, JMJD4, Prognosis

© 2017 biocloud.net版权所有 ICP证：京10042835号