Effects of SOX15 on the colorectal cancer cells via downregulation of the Wnt/β-catenin signaling pathway.
[No authors listed]
摘要
AIM:To detect the function and mechanism of SOX15 in colorectal cancer. MATERIALS & METHODS:The expression of SOX15 in colorectal cancer (CRC) cells and tissues was detected by real-time PCR, quantitative real-time PCR and immunohistochemistry. The overexpression of SOX15 in cells was tested by western blot, CCK-8, FACS analysis, transwell and clone assay. Moreover, SOX15 regulated Wnt pathway investigated by western blot. RESULTS:We found that SOX15 has a low-expression in CRC cells and tissues. Overexpression of SOX15 can inhibit the proliferation, migration and invasion of cells and induce cells apoptosis. Furthermore, SOX15 could be the inhibitor of Wnt/β-catenin pathway in CRC. CONCLUSION:SOX15 can be a tumor suppressor in CRC by suppressing the Wnt/β-catenin signaling pathway.
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基因功能
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原始数据
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文献解读
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