例如："lncRNA", "apoptosis", "WRKY"

S-Nitrosylation Targets GSNO Reductase for Selective Autophagy during Hypoxia Responses in Plants.

Mol. Cell. 2018 Jul 05;71(1):142-154.e6. Epub 2018 Jun 28
Ni Zhan 1 , Chun Wang 2 , Lichao Chen 1 , Huanjie Yang 1 , Jian Feng 1 , Xinqi Gong 3 , Bo Ren 4 , Rong Wu 1 , Jinye Mu 4 , Yansha Li 1 , Zhonghua Liu 5 , Ying Zhou 6 , Juli Peng 4 , Kejian Wang 7 , Xun Huang 5 , Shi Xiao 6 , Jianru Zuo 8
Ni Zhan 1 , Chun Wang 2 , Lichao Chen 1 , Huanjie Yang 1 , Jian Feng 1 , Xinqi Gong 3 , Bo Ren 4 , Rong Wu 1 , Jinye Mu 4 , Yansha Li 1 , Zhonghua Liu 5 , Ying Zhou 6 , Juli Peng 4 , Kejian Wang 7 , Xun Huang 5 , Shi Xiao 6 , Jianru Zuo 8
+ et al

[No authors listed]

Author information
  • 1 State Key Laboratory of Plant Genomics and CAS Center for Excellence in Molecular Plant Sciences, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
  • 2 State Key Laboratory of Plant Genomics and CAS Center for Excellence in Molecular Plant Sciences, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; State Key Laboratory of Rice Biology, China National Rice Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310006, China.
  • 3 Institute for Mathematical Sciences, Renmin University of China, Beijing 100872, China.
  • 4 State Key Laboratory of Plant Genomics and CAS Center for Excellence in Molecular Plant Sciences, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
  • 5 State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
  • 6 State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
  • 7 State Key Laboratory of Rice Biology, China National Rice Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310006, China.
  • 8 State Key Laboratory of Plant Genomics and CAS Center for Excellence in Molecular Plant Sciences, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: jrzuo@genetics.ac.cn.

摘要

Nitric oxide (NO) regulates diverse cellular signaling through S-nitrosylation of specific Cys residues of target proteins. The intracellular level of S-nitrosoglutathione (GSNO), a major bioactive NO species, is regulated by GSNO reductase (GSNOR), a highly conserved master regulator of NO signaling. However, little is known about how the activity of GSNOR is regulated. Here, we show that S-nitrosylation induces selective autophagy of Arabidopsis GSNOR1 during hypoxia responses. S-nitrosylation of GSNOR1 at Cys-10 induces conformational changes, exposing its AUTOPHAGY-RELATED8 (ATG8)-interacting motif (AIM) accessible by autophagy machinery. Upon binding by ATG8, GSNOR1 is recruited into the autophagosome and degraded in an AIM-dependent manner. Physiologically, the S-nitrosylation-induced selective autophagy of GSNOR1 is relevant to hypoxia responses. Our discovery reveals a unique mechanism by which S-nitrosylation mediates selective autophagy of GSNOR1, thereby establishing a molecular link between NO signaling and autophagy.

KEYWORDS: GSNO reductase, S-nitrosylation, hypoxia responses, nitric oxide, selective autophagy

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