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Linker histone H1FOO regulates the chromatin structure in mouse zygotes.

FEBS Lett.2018 Jul;592(14):2414-2424. doi:10.1002/1873-3468.13175. Epub 2018 Jul 16
Satoshi Funaya 1 , Masatoshi Ooga 1 , Masataka G Suzuki 1 , Fugaku Aoki 1
Satoshi Funaya 1 , Masatoshi Ooga 1 , Masataka G Suzuki 1 , Fugaku Aoki 1

[No authors listed]

Author information
  • 1 Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.

摘要


The chromatin structure in one-cell-stage mouse embryos is extremely loose and becomes tighter at the two-cell stage. As linker histones are involved in higher-order chromatin structure, we examined the involvement of the linker histone variant H1foo in the change of chromatin looseness between the one- and two-cell stages. H1foo knockdown causes the chromatin structure to be tighter in the pronucleus and increases deposition of the histone H3 variant H3.1/3.2 in the peripheral region of the pronucleus in one-cell-stage embryos. The decrease in chromatin looseness at the two-cell stage is less after overexpressing H1foo. These results suggest that H1foo is involved in the change in chromatin structure via nuclear deposition of H3 variants between the one- and two-cell stages.

KEYWORDS: H1foo, chromatin structure, linker histone, mouse embryo, zygote