Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure.

Elife. 2018 Jun 19;7

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mutants leads to distended ear tissue. Using serial-section electron microscopy and adaptive optics lattice light-sheet microscopy, we find a pressure relief valve in the ES comprised of partially separated apical junctions and dynamic overlapping basal lamellae that separate under pressure to release fluid. We propose that this lmx1-dependent pressure relief valve is required to maintain fluid homeostasis in the inner ear and other fluid-filled cavities.

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Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure.

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