例如:"lncRNA", "apoptosis", "WRKY"

Codeine-induced acute generalized exanthematous pustulosis without IL36RN mutations.

Pharmacogenomics. 2018 Jul 01;19(11):889-893. doi:10.2217/pgs-2017-0200. Epub 2018 Jun 19
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摘要


Recent studies have suggested an association between mutations in the IL-36RN gene and the onset of pustular generalized. In the literature, only one case of acute generalized exanthematous pustulosis (AGEP) induced by codeine in a patient with IL36RN mutation has been reported. Herein, we reported an unusual case of AGEP caused by codeine in a patient with a history of psoriasis and confirmed by an oral provocation test. In this case, we have shown that the IL36RN gene mutation is not a constant condition in drug-induced AGEP. Clinicians should be aware of this side effect of codeine especially, in patients with a history of psoriasis. More studies are needed to clarify the association between drug-induced AGEP and IL36RN gene mutations.

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