Germline Stem Cell Heterogeneity Supports Homeostasis in Drosophila.
Stem Cell Reports. 2018 Jul 10;11(1):13-21. Epub 2018 Jun 07
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摘要
Adult and embryonic stem cells exhibit fluctuating gene expression; however, the biological significance of stem cell heterogeneity is not well understood. We show that, in Drosophila, female germline stem cells (GSCs) exhibit heterogeneous expression of a GSC differentiation-promoting factor Regena (Rga). The Drosophila homolog of human SON, dsn, is required to maintain GSC heterogeneity by suppressing sustained high levels of Rga. Reducing the expression of Rga in dsn mutants restores GSC heterogeneity and self-renewal. Thus, GSC heterogeneity is linked to GSC homeostasis.
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基因功能
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原始数据
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文献解读
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