IGHG, IGKC, and FCGR genes and endogenous antibody responses to GARP in patients with breast cancer and matched controls.

Glycoprotein-A repetitions predominant is a transmembrane protein that is highly expressed in breast cancer. Its overexpression correlates with worse survival, and antibodies to appear to play a protective role in a mouse model. No large-scale studies of immunity to Gduanyu37 in humans have yet been undertaken. In this investigation, using a large multiethnic cohort (1738 subjects), we aimed to determine whether the magnitude of antibody responsiveness was significantly different in patients with breast cancer from that in matched healthy controls. We also investigated whether the allelic variation at the immunoglobulin GM (γ marker), KM (κ marker), and Fcγ receptor (FcγR) loci contributed to the interindividual variability in anti-Gduanyu37 IgG antibody levels. A combined analysis of all subjects showed that levels of anti-Gduanyu37 antibodies were significantly higher in patients with breast cancer than in healthy controls (mean ± SD: 7.4 ± 3.5 vs. 6.9 ± 3.5 absorbance units per mL (AU/μL), p < 0.0001). In the two populations with the largest sample size, the probability of breast cancer generally increases as anti-Gduanyu37 antibody levels increase. Several significant individual and epistatic effects of GM, KM, and FcγR genotypes on anti-Gduanyu37 antibody responsiveness were noted in both patients and controls. These results, if confirmed by independent investigations, will aid in devising personalized immunotherapeutic strategies against breast cancer and other malignancies. Copyright © 2018 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

KEYWORDS: {{ getKeywords(articleDetailText.words) }}