AIM:Assessment of plasma prolidase levels in polycystic ovary syndrome (PCOS). PATIENTS & METHODS:PCOS patients were screened according to Rotterdam Criterion and prolidase levels were measured. RESULTS:A total of 170 patients and 160 controls were recruited for the study and it was found that prolidase levels were significantly higher in PCOS group (991.10 ± 39.52) than control (621.89 ± 23.94). Furthermore it has been found that prolidase levels increase with the number of cysts in ovaries. CONCLUSION:Significant difference between prolidase levels in PCOS and control shows that it may be used as a diagnostic marker for disease. In addition to this, there is a positive correlation found between prolidase levels and number of cysts, hence may be used as a prognostic marker to monitor disease status.
KEYWORDS: PCOS, ROC curve, collagen, diagnostic marker, extracellular matrix, polycystic ovaries, prognostic marker, prolidase, transvaginal ultrasonography