[No authors listed]
Breast cancer is the second leading cause of cancerâassociated mortalities in women. Tamoxifen (TAM) is an endocrine therapy commonly used in the treatment of patients with breast cancer expressing estrogen receptor α. However, treatment often ends in failure due to the emergence of drug resistance. MicroRNAs (miRNAs), a family of small nonâcoding RNAs, serve critical roles in the regulation of gene expression and cell events. To date, whether miRNAâ663b could mediate TAM resistance in breast cancer remains unknown. Therefore, the aim of the present study was to investigate the role of miRNAâ663b in TAM resistance in breast cancer. The results demonstrated that miRNAâ663b was upregulated in breast cancer with TAM resistance. Tumor protein 73 (TP73) was a direct target of miRNAâ663b, and was negatively regulated by miRNAâ663b in MCFâ7 cells. Furthermore, it was identified that downregulation of miRNAâ663b inhibited cell proliferation ability and promoted cell apoptosis, resulting in enhanced TAM sensitivity. In addition, these findings suggested that TP73 silencing may have eliminated the effects of miRNAâ663b inhibitor on breast cancer cells. In conclusion, the present study verified a novel molecular link between miRNAâ663b and TP73, and indicated that miRNAâ663b may be a critical therapeutic target in breast cancer.
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