Genome-wide distribution of linker histone H1.0 is independent of MeCP2.

Nat. Neurosci.2018 Jun;21(6):794-798. Epub 2018 May 25

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Previous studies suggested that MeCP2 competes with linker histone H1, but this hypothesis has never been tested in vivo. Here, we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) of Flag-tagged-H1.0 in mouse forebrain excitatory neurons. Unexpectedly, Flag-H1.0 and MeCP2 occupied similar genomic regions and the Flag-H1.0 binding was not changed upon MeCP2 depletion. Furthermore, mild overexpression of H1.0 did not alter MeCP2 binding, suggesting that the functional binding of MeCP2 and H1.0 are largely independent.

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Genome-wide distribution of linker histone H1.0 is independent of MeCP2.

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