Role of GW182 protein in the cell.
Int J Biochem Cell Biol. 2018 Aug;101:29-38. Epub 2018 May 20
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摘要
GW182 proteins interact directly with the argonaute proteins and constitute key components of miRNA repressor complexes (miRISC) in metazoans. As argonautes are insufficient for silencing they recruit the GW182â¯s that act as scaffold proteins inducing downstream translational repression, target mRNA deadenylation and exonucleolytic mRNA degradation. Besides their role as part of repressor complexes inside the cell, they function in wide variety of cellular processes as highlighted in this review. The present review summarises and discusses in detail our current knowledge of the GW182â¯s and their role inside the cell.
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基因功能
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原始数据
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文献解读
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