Identifying the SUMO1 modification of FAM122A leading to the degradation of PP2A-CÎ± by ubiquitin-proteasome system.

Biochem. Biophys. Res. Commun.2018 Jun 07;500(3):676-681. Epub 2018 Apr 22

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FAM122A is a highly conserved protein in mammals. Here, we identify that FAM122A can be sumoylated at lysine 89, which can be de-conjugated by SENP1. Furthermore, the sumoylation of FAM122A reduces the PP2A-CÎ± protein level together with the reduced phosphatase activity of PP2A, which suppresses cell proliferation. Collectively, our results suggest that the sumoylation of FAM122A may have a significant role in cellular function.

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Identifying the SUMO1 modification of FAM122A leading to the degradation of PP2A-CÎ± by ubiquitin-proteasome system.

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