例如："lncRNA", "apoptosis", "WRKY"

Identifying the SUMO1 modification of FAM122A leading to the degradation of PP2A-Cα by ubiquitin-proteasome system.

Biochem. Biophys. Res. Commun.2018 Jun 07;500(3):676-681. Epub 2018 Apr 22
Fangzhi Fan 1 , Junxing Zhao 2 , Yali Liu 3 , Hongfang Zhao 3 , Lietao Weng 1 , Qingqing Li 2 , Guoqiang Chen 4 , Ying Xu 5
Fangzhi Fan 1 , Junxing Zhao 2 , Yali Liu 3 , Hongfang Zhao 3 , Lietao Weng 1 , Qingqing Li 2 , Guoqiang Chen 4 , Ying Xu 5
+ et al

[No authors listed]

Author information
  • 1 Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • 2 Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • 3 Institute of Health Sciences, Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences and SJTU-SM, Shanghai 200025, China.
  • 4 Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • 5 Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: yingxuxu@shsmu.edu.cn.

摘要

FAM122A is a highly conserved protein in mammals. Here, we identify that FAM122A can be sumoylated at lysine 89, which can be de-conjugated by SENP1. Furthermore, the sumoylation of FAM122A reduces the PP2A-Cα protein level together with the reduced phosphatase activity of PP2A, which suppresses cell proliferation. Collectively, our results suggest that the sumoylation of FAM122A may have a significant role in cellular function.

KEYWORDS: FAM122A, PP2A, Phosphatase activity, SUMO1 modification, Ubiquitination

© 2017 biocloud.net版权所有 ICP证：京10042835号