A switch-variant model integrates the functions of an autoimmune variant of the phosphatase PTPN22.
Sci Signal. 2018 Apr 17;11(526)
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摘要
The R620W polymorphism in protein tyrosine phosphatase nonreceptor type 22 (PTPN22) predisposes carriers to several autoimmune diseases. Two papers in Science Immunology and Science Signaling on this human disease-associated variant lead us to propose a new "switch-of-function" model.
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基因功能
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原始数据
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文献解读
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