Clinicopathological and prognostic significance of MUC13 and AGR2 expression in intraductal papillary mucinous neoplasms of the pancreas.

BACKGROUND:Intraductal papillary mucinous neoplasm of the pancreas is a primary pancreatic ductal epithelial neoplasm with the potential to develop into an invasive adenocarcinoma. This study aimed to investigate the clinicopathologic and prognostic significance of four potential biomarkers for the preoperative evaluation of patients with AND METHODS:Clinicopathologic materials from 104 patients with who underwent surgical resection at Jichi Medical University Hospital were analyzed. (110 lesions in total) were histologically classified into low-grade Iduanyu1451 (Group 1; n = 68), high-grade Iduanyu1451 (Group 2; n = 16), or Iduanyu1451 with an associated invasive carcinoma (Group 3; n = 26). We evaluated the immunohistochemical expression of MUC13, AGR2, FUT8, and FXYD3, which were previously reported to be overexpressed in pancreatic ductal adenocarcinoma. RESULTS:The expression of MUC13 was more common in Group 3 compared with groups 1 and 2 (p < 0.001) and was associated with poor prognosis (p = 0.004). The expression of MUC13 was not associated with age, sex, tumor location, histological subtype, lymphatic or vascular invasion, or neural invasion. In most cases of the loss of expression of AGR2 appeared to show an association with tumor recurrence and poorly differentiated histology of invasive carcinoma; however, this association was not statistically significant. The expressions of FUT8 and FXYD3were not associated with the clinicopathological features of results suggest that MUC13 overexpression and loss of expression of AGR2 may predict the progression of Iduanyu1451 and an unfavorable prognosis in patients with

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