例如:"lncRNA", "apoptosis", "WRKY"

Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells.

Immunity. 2018 Apr 17;48(4):760-772.e4. Epub 2018 Apr 03
Kristina S Burrack 1 , Matthew A Huggins 2 , Emily Taras 3 , Philip Dougherty 3 , Christine M Henzler 4 , Rendong Yang 4 , Sarah Alter 5 , Emily K Jeng 5 , Hing C Wong 5 , Martin Felices 3 , Frank Cichocki 3 , Jeffrey S Miller 3 , Geoffrey T Hart 6 , Aaron J Johnson 7 , Stephen C Jameson 1 , Sara E Hamilton 8
Kristina S Burrack 1 , Matthew A Huggins 2 , Emily Taras 3 , Philip Dougherty 3 , Christine M Henzler 4 , Rendong Yang 4 , Sarah Alter 5 , Emily K Jeng 5 , Hing C Wong 5 , Martin Felices 3 , Frank Cichocki 3 , Jeffrey S Miller 3 , Geoffrey T Hart 6 , Aaron J Johnson 7 , Stephen C Jameson 1 , Sara E Hamilton 8
+ et al

[No authors listed]

Author information
  • 1 Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55414, USA.
  • 2 Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55414, USA; Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
  • 3 Department of Medicine, University of Minnesota, Minneapolis, MN 55414, USA.
  • 4 Supercomputing Institute for Advanced Computational Research, University of Minnesota, Minneapolis, MN 55414, USA.
  • 5 Altor BioScience Corporation, Miramar, FL 33025, USA.
  • 6 Center for Immunology, Department of Medicine, University of Minnesota, Minneapolis, MN 55414, USA.
  • 7 Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
  • 8 Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55414, USA. Electronic address: hamil062@umn.edu.

摘要


Cerebral malaria is a deadly complication of Plasmodium infection and involves blood brain barrier (BBB) disruption following infiltration of white blood cells. During experimental cerebral malaria (ECM), mice inoculated with Plasmodium berghei ANKA-infected red blood cells develop a fatal CM-like disease caused by CD8+ T cell-mediated pathology. We found that treatment with interleukin-15 complex (IL-15C) prevented ECM, whereas IL-2C treatment had no effect. IL-15C-expanded natural killer (NK) cells were necessary and sufficient for protection against ECM. IL-15C treatment also decreased CD8+ T cell activation in the brain and prevented BBB breakdown without influencing parasite load. IL-15C induced NK cells to express IL-10, which was required for IL-15C-mediated protection against ECM. Finally, we show that ALT-803, a modified human IL-15C, mediates similar induction of IL-10 in NK cells and protection against ECM. These data identify a regulatory role for cytokine-stimulated NK cells in the prevention of a pathogenic immune response. Copyright © 2018 Elsevier Inc. All rights reserved.

KEYWORDS: CD8(+) T cells, IL-10, IL-15, NK cells, cerebral malaria, cytokine complexes, immunopathology