The CPLANE protein Intu protects kidneys from ischemia-reperfusion injury by targeting STAT1 for degradation.

Intu is known as a ciliogenesis and planar polarity effector (CPLANE) protein. Although roles for Intu have been reported during embryonic development and in the context of developmental disorders, its function and regulation in adult tissues remain poorly understood. Here we show that ablation of Intu specifically in kidney proximal tubules aggravates renal ischemia-reperfusion injury, and leads to defective post-injury ciliogenesis. We identify signal transducer and activator of transcription 1 as a novel interacting partner of Intu. In vitro, Intu and colocalize at the centriole/basal body area, and Intu promotes proteasomal degradation of During cell stress, Intu expression preserves cilia length and cell viability, and these actions are antagonized by duanyu18131 expression. Thus, we propose a role for Intu in protecting cells and tissues after injury by targeting duanyu18131 for degradation and maintaining primary cilia.

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