The CSR-1 endogenous RNAi pathway ensures accurate transcriptional reprogramming during the oocyte-to-embryo transition in Caenorhabditis elegans.

Endogenous is a conserved mechanism for fine-tuning gene expression. In the nematode Caenorhabditis elegans, several pathways are required for the successful development of reproductive cells. The CSR-1 endoduanyu1615 pathway promotes germ cell development, primarily by facilitating the expression of germline genes. In this study, we report a novel function for the CSR-1 pathway in preventing premature activation of embryonic transcription in the developing oocytes, which is accompanied by a general Pol II activation. This CSR-1 function requires its RNase activity, suggesting that, by controlling the levels of maternal mRNAs, CSR-1-dependent endoduanyu1615 contributes to an orderly reprogramming of transcription during the oocyte-to-embryo transition.

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