Role of IGFBP6 Protein in the Regulation of Epithelial-Mesenchymal Transition Genes.
Bull. Exp. Biol. Med.2018 Mar;164(5):650-654. Epub 2018 Mar 26
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摘要
Protein IGFBP6 plays an important role in the pathogenesis of many malignant tumors, including breast cancer. The relationship between IGFBP6 protein and the expression of genes associated with the epithelial-mesenchymal transition is studied. Gene IGFBP6 knockdown does not trigger the epithelial-mesenchymal transition in MDA-MB-231 cells, but modifies significantly the expression of many genes involved in this process. A decrease of IGFBP6 expression can involve a decrease in the expression of N-cadherin and transcription factor Slug.
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基因功能
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原始数据
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文献解读
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