Reactive oxygen species participate in liver function recovery during compensatory growth in zebrafish (Danio rerio).
[No authors listed]
摘要
Compensatory growth (CG) is defined as a phase of accelerated growth when the disadvantageous environment is improved, accompanied by metabolic adjustment. Here, we report that hepatic oxidative phosphorylation (OXPHOS) activity was enhanced during compensatory growth in zebrafish. Mitochondrial metabolism enabled the generation of reactive oxygen species which activated the nrf2 (nuclear factor-erythroid 2-related factor 2) signaling pathway, as well as the mTOR signaling pathway. Tempol (a superoxide dismutase mimetic) treatment blocked signaling in the liver as well as CG in zebrafish. These results demonstrated that mitochondrial duanyu1670 signaling are essential for the occurrence of compensatory growth in zebrafish.
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基因功能
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原始数据
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文献解读
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