Overexpression of Derlin-1 is Associated with Poor Prognosis in Patients with Non-small Cell Lung Cancer.

BACKGROUND:Recent studies indicated that Derlin-1 has an important function in cancer progression. However, its expression pattern and relationships with clinicopathologic characteristics in non-small cell lung cancer (NSCLC) have not been completely found. In the current study, we aimed to evaluate the prognostic significance of Derlin-1 in NSCLC. METHODS:Cancer tissues and paracancer tissues were collected from 168 patients with NSCLC. The expression of Derlin-1 was detected by RT-PCR, Western blot, and immunohistochemistry. The correlation between Derlin-1 expression and various clinicopathologic features was investigated. RESULTS:The results showed that mRNA and protein of Derlin-1 was overexpressed in NSCLC and the positive rate of Derlin-1 was significantly correlated with TNM stage, histologic grade, lymph node metastasis and overall survival. CONCLUSION:Derlin-1 is overexpressed in NSCLC and promotes the malignancy of NSCLC. Derlin-1 maybe served as a potential therapeutic target for NSCLC.

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