Generation and Characterization of a CYP2C11-Null Rat Model by Using the CRISPR/Cas9 Method.
Drug Metab. Dispos.2018 May;46(5):525-531. Epub 2018 Feb 14
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摘要
CYP2C11 is involved in the metabolism of many drugs in rats. To assess the roles of CYP2C11 in physiology and drug metabolism, a CYP2C11-null rat model was generated using the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 and intrinsic-null rat model was successfully generated and is a valuable tool to study the in vivo function of CYP2C11.
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基因功能
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原始数据
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文献解读
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