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Association of IL33 and IL1RAP Polymorphisms With Acute Anterior Uveitis.

Curr. Mol. Med.2018 Mar 09;17(7):471-477
X-F Huang 1 , W Chi 2 , D Lin 1 , M-L Dai 1 , Y-L Wang 3 , Y-M Yang 4 , Z-B Jin 1 , Y Wang 1
X-F Huang 1 , W Chi 2 , D Lin 1 , M-L Dai 1 , Y-L Wang 3 , Y-M Yang 4 , Z-B Jin 1 , Y Wang 1
+ et al

[No authors listed]

Author information
  • 1 The Eye Hospital, Wenzhou Medical University, Wenzhou, China.
  • 2 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
  • 3 The Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
  • 4 Wenzhou People's Hospital, Wenzhou Physical Examination Center, Wenzhou, China.

摘要


BACKGROUND:AAU (acute anterior uveitis) is the most common entity of uveitis characterized by acute vision loss and violent sore eyes. IL-33 and IL-1RacP have been found to play crucial roles in the innate immune system. OBJECTIVE:In the present study, we investigated the association of IL33 and IL1RAP genes with AAU. METHOD:A total of 549 AAU patients and 1080 unrelated healthy controls were recruited for this study. Ten single nucleotide polymorphisms (SNPs) were genotyped using Sequenom Mass ARRAY technology. RESULTS:Our findings demonstrated that IL1RAP-rs3773978 significantly associated with AAU and could serve as a genetic risk marker in Chinese AAU patients. A significantly increased frequency of the A allele and AA homozygosity of IL1RAP-rs3773978 was observed in AAU patients compared with that in controls (p=0.001, pc=0.01, OR=1.282, 95% CI 1.106 to 1.487; p=0.0003, pc=0.003, OR=1.647, 95% CI 1.255 to 2.163, respectively). Further stratification analyses showed that the genetic correlation may differ depending on HLA-B27 status, AS (ankylosing spondylitis) status, attack times and laterality status. CONCLUSION:Our findings provide new insights that enhance the current knowledge of uveitis genetics by demonstrating the specific functional roles of IL1RAP and other IL-1 family genes in uveitis.

KEYWORDS: IL1RAP, IL33, acute anterior uveitis, association analysis, innate immune system, vision loss.