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An evolutionarily conserved gene family encodes proton-selective ion channels.

Science. 2018 Mar 02;359(6379):1047-1050. Epub 2018 Jan 25
Yu-Hsiang Tu 1 , Alexander J Cooper 1 , Bochuan Teng 1 , Rui B Chang 1 , Daniel J Artiga 1 , Heather N Turner 1 , Eric M Mulhall 1 , Wenlei Ye 2 , Andrew D Smith 3 , Emily R Liman 4
Yu-Hsiang Tu 1 , Alexander J Cooper 1 , Bochuan Teng 1 , Rui B Chang 1 , Daniel J Artiga 1 , Heather N Turner 1 , Eric M Mulhall 1 , Wenlei Ye 2 , Andrew D Smith 3 , Emily R Liman 4
+ et al

[No authors listed]

Author information
  • 1 Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA.
  • 2 Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA 90089, USA. liman@usc.edu.
  • 3 Department of Biological Sciences, Section of Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA.
  • 4 Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.

摘要

ortholog also encode proton channels. Evolutionary conservation of the gene family and its widespread tissue distribution suggest a broad role for proton channels in physiology and pathophysiology.

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