Med1 deficiency alters the somatic hypermutation spectrum in murine B cells.
Eur. J. Immunol.2018 Apr;48(4):720-723. doi:10.1002/eji.201747258. Epub 2018 Feb 14
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摘要
The Mediator complex is known to orchestrate transcription. Here we show that B cell conditional deficient mice for the Med1 subunit display robust somatic hypermutation. Nevertheless, the mutation frequency at A residues is decreased and the expected A/T ratio is abolished, implicating Mediator in the second phase of somatic hypermutation.
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基因功能
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原始数据
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文献解读
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