[No authors listed]
Glioblastoma multiforme (GBM), a World Health Organization grade IV glioma, is the most common and aggressive primary brain tumor in humans. microRNAs (miRNAs) are aberrantly expressed in numerous cancer types, including GBM. Abnormally expressed miRNAs are commonly associated with malignant characteristics of GBM, including malignant growth, proliferation, apoptosis, invasion, metastasis and resistance to chemotherapy. miRNA (miR)â376a is abnormally expressed in multiple human cancers; however, the expression pattern and role of miRâ376a in GBM, and the underlying molecular mechanisms by which miRâ376a exerts its functions remain to be elucidated. Therefore, the aim of this study was to measure miRâ376a expression and determine its biological roles in GBM as well as its associated molecular mechanism. In the present study, miRâ376a expression was markedly downregulated in GBM tissues and cell lines. Overexpression of miRâ376a markedly decreased the proliferation and invasion of GBM cells in vitro. In the present study, specificity protein 1 (SP1) was demonstrated to be a direct target of miRâ376a. In addition, a negative association between SP1 mRNA and miRâ376a expression was observed in GBM tissues. SP1 upregulation reduced the effects of miRâ376a overexpression on GBM cell proliferation and invasion. miRâ376a may be a therapeutic target for the treatment of patients with GBM.
KEYWORDS: {{ getKeywords(articleDetailText.words) }}
Sample name | Organism | Experiment title | Sample type | Library instrument | Attributes | |||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
{{attr}} | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
{{ dataList.sampleTitle }} | {{ dataList.organism }} | {{ dataList.expermentTitle }} | {{ dataList.sampleType }} | {{ dataList.libraryInstrument }} | {{ showAttributeName(index,attr,dataList.attributes) }} |
{{ list.authorName }} {{ list.authorName }} |