Contradictory intrahepatic immune responses activated in high-load hepatitis C virus livers compared with low-load livers.
Arch. Virol.2018 Apr;163(4):855-865. Epub 2017 Dec 16
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摘要
T helper cell) was upregulated in the HCV-high group compared with the HCV-low group. The immune regulatory molecules FOXP3 mRNA (regulatory T cell, T reg) and programmed cell death ligand-1 (PD-L1) mRNA were significantly increased in the HCV-high group. HCV-high livers had two molecular immune responses: increased APC numbers and adaptive immunity and the induction of immune tolerance. The local hepatic imbalance of contradictory immune responses might be responsible for high HCV loads.
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基因功能
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原始数据
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文献解读
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