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Potential Roles of GLUT12 for Glucose Sensing and Cellular Migration in MCF-7 Human Breast Cancer Cells Under High Glucose Conditions.

Anticancer Res.2017 Dec;37(12):6715-6722
Chihiro Matsui 1 , Tomoka Takatani-Nakase 2 , Sachie Maeda 1 , Ikuhiko Nakase 3 , Koichi Takahashi 2
Chihiro Matsui 1 , Tomoka Takatani-Nakase 2 , Sachie Maeda 1 , Ikuhiko Nakase 3 , Koichi Takahashi 2

[No authors listed]

Author information
  • 1 Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.
  • 2 Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan nakase@mukogawa-u.ac.jp i-nakase@21c.osakafu-u.ac.jp koichi@mukogawa-u.ac.jp.
  • 3 NanoSquare Research Institute, Research Center for the 21st Century, Organization for Research Promotion, Osaka Prefecture University, Sakai, Japan nakase@mukogawa-u.ac.jp i-nakase@21c.osakafu-u.ac.jp koichi@mukogawa-u.ac.jp.

摘要


BACKGROUND/AIM:Recent reports have indicated that hyperglycaemia is associated with breast cancer progression. High glucose conditions corresponding to hyperglycaemia significantly promote migration of MCF-7 human breast cancer cells, however, little is known about the mechanisms of glucose sensing for the acquisition of migratory properties by MCF-7 cells. This study investigated glucose sensing and mediation, which are responsible for the high motility of MCF-7 cells. MATERIALS AND METHODS:We evaluated the migration of MCF-7 cells cultured in high glucose-containing medium and essential regulatory factors from the perspective of the glucose transport system. RESULTS:We demonstrated that glucose transporter 12 (GLUT12) protein level increased in MCF-7 cells and co-localized with actin organization under high glucose conditions. Moreover, GLUT12-knockdown completely abrogated high glucose-induced migration, indicating that GLUT12 functionally participates in sensing high glucose concentrations. CONCLUSION:GLUT12 plays a critical role in the model of breast cancer progression through high glucose concentrations.

KEYWORDS: GLUT12, MCF-7 Human breast cancer cells, cell migration, high glucose, hyperglycaemia