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The killer cell lectin-like receptor B1 (KLRB1) 503T>C polymorphism (rs1135816) and acute rejection after liver transplantation.

HLA. 2018 Jan;91(1):52-55. doi:10.1111/tan.13172
H Thude 1 , S Rother 2 , M Sterneck 1 , J Klempnauer 2 , B Nashan 1 , R Schwinzer 2 , M Koch 1
H Thude 1 , S Rother 2 , M Sterneck 1 , J Klempnauer 2 , B Nashan 1 , R Schwinzer 2 , M Koch 1
+ et al

[No authors listed]

Author information
  • 1 Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • 2 Department of General, Visceral and Transplantation Surgery, Transplant Laboratory, Hannover Medical School, Hannover, Germany.

摘要

The killer cell lectin-like receptor B1 (KLRB1) gene encodes for CD161 expressed by different subsets of leukocytes involved in the development of acute liver transplant rejection. The single nucleotide polymorphism (SNP) 503T>C (rs1135816) in the KLRB1 gene represents a missense mutation modifying functional properties of CD161. The aim of our study is to determine whether the SNP 503T>C is associated with acute liver transplant rejection. We genotyped the SNP for 163 liver recipients without acute rejection, 125 recipients with a single acute rejection, and 53 recipients with multiple acute rejections. The genotype frequencies within the groups did not show any significant difference. Our data suggest that the SNP 503T>C has no impact on the susceptibility of acute liver transplant rejection.

KEYWORDS: CD161, acute rejection, killer cell lectin-like receptor B1, liver transplantation

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